Practical synthesis of iodo phenothiazines. A facile access to electrophore building blocks

M Sailer, RA Gropeanu, TJJ Müller

Index: Sailer, Markus; Gropeanu, Radu-Adrian; Mueller, Thomas J. J. Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7509 - 7512

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Citation Number: 29

Abstract

Bromine-lithium exchange of the mono-and dibromophenothiazines 1 and 3a regiospecifically furnishes upon electrophilic trapping with iodine the iodo-and diiodophenothiazines 2, 3b, and 3d in excellent yield. The 3-bromo-7-iodophenothiazine 3d can be submitted to regioselective and sequential Suzuki coupling reactions with phenothiazine mono-and bisboronates 4 and 5 and/or (hetero) aryl boronic acids to give ...