An efficient, diastereoselective route to 2, 5, 6, 7-tetrasubstituted-1 H-pyrrolo [1, 2-c] imidazoles has been developed using solid-phase intramolecular azomethine ylide cycloaddition and carbanilide cyclization chemistries. To successfully execute this eight-step protocol in the solid phase, it was necessary to insert a spacer moiety between the resin and glycinate functional group. Experiments addressing the stereoselectivity of the 1, 3-dipolar ...
