Conformationally restricted congeners of hypotensive and platelet aggregation inhibitors: 6-aryl-5-methyl-4, 5-dihydro-3 (2H)-pyridazinones derived from 5H-indeno [1 …

G Cignarella, D Barlocco, GA Pinna…

Index: Cignarella, Giorgio; Barlocco, Daniela; Pinna, Gerard A.; Loriga, Mario; Tofanetti, Odoardo; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2191 - 2194

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Citation Number: 10

Abstract

A number of 7-amino and 7-acylamino substituted 4, 4a-dihydro-5H-indeno [1, 2-c] pyridazii- 3-0nes have been synthesized as rigid congeners of hypotensive 6-aryl-5-methyl-4, 5- dihydro-3 (2H)-pyridazinones and tested as antihypertensive, antithrombotic, antiulcer, and antiinflammatory agents. Unlike the previously described 7-cyano derivative, which displayed only antiinflammatory action, the new series exhibited significant ...