Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization

…, DS Karanewsky, RJ Ternansky, N Chen, X Guo…

Index: Linton, Steven D.; Karanewsky, Donald S.; Ternansky, Robert J.; Chen, Ning; Guo, Xian; Jahangiri, Kathy G.; Kalish, Vincent J.; Meduna, Steven P.; Robinson, Edward D.; Ullman, Brett R.; Wu, Joe C.; Pham, Brian; Kodandapani, Lalitha; Smidt, Robert; Diaz, Jose-Luis; Fritz, Lawrence C.; Von Krosigk; Roggo, Silvio; Schmitz, Albert; Tomaselli, Kevin J. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2973 - 2975

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Citation Number: 22

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low nanomolar broad spectrum activity, in particular, single digit nanomolar inhibitory activity against caspase 8.