Tetrahedron

Synthesis of functionalized thiazoles via attack of heterocyclic nucleophiles on allenyl isothiocyanates

BJ Al-Hourani, K Banert, N Gomaa, K Vrobel

Index: Jawabrah Al-Hourani, Baker; Banert, Klaus; Gomaa, Nermeen; Vrobel, Kai Tetrahedron, 2008 , vol. 64, # 23 p. 5590 - 5597

Full Text: HTML

Citation Number: 11

Abstract

New examples of substituted thiazole derivatives carrying different heterocyclic ring systems at C-2 position were prepared via the reaction of several allenyl isothiocyanates with nucleophiles such as imidazoles, pyrazoles, benzimidazoles, indazole, 1, 2, 3-triazole, 1, 2, 4-triazole, and 1H-benzotriazole. Although these allenyl isothiocyanates are very reactive electrophiles and tend to polymerize, the yield of the thiazole products ranked between ...