… -1, 3-(2 H, 4 H)-diones and 4-[(Pyridylmethyl) aminomethylene] isoquinoline-1, 3-(2 H, 4 H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase …

HR Tsou, X Liu, G Birnberg, J Kaplan…

Index: Brown, T. H.; Blakemore, R. C.; Durant, G. J.; Ganellin, C. R.; Parsons, M. E.; et al. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 601 - 608

Full Text: HTML

Citation Number: 29

Abstract

... Journal of Medicinal ... 2 , −78 °C; then NaN 3 , DMF, room temperature; (xi) PPh 3 , THF, H 2 O, room temperature; (xii) NH 4 OH, then I 2 , KI, H 2 O; (xiii) Et 3 N ... In addition, heteroaryl groups were introduced as methoxy replacements at the C-4 of the benzylamine headpiece in 5d ...