Mutagenicity of isomeric alkanediazotates, precursors for ultimate alkylating species of carcinogenic N-nitroso compounds

S Ukawa-Ishikawa, A Sawada, K Kasuya…

Index: Ukawa-Ishikawa, Satoko; Sawada, Atsuko; Kasuya, Keiko; Mochizuki, Masataka Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 1998 , vol. 412, # 1 p. 99 - 107

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Citation Number: 7

Abstract

Alkanediazohydroxides are common key intermediates in carcinogenesis and mutagenesis of N-nitroso compounds, which are widely found in human environment. Mutagenicity of (E)- and (Z)-potassium alkanediazotates, as precursors of corresponding alkanediazohydroxides were evaluated to investigate the effect of geometric isomerism and also the effect of alkyl groups on their biological activity. Mutagenicity of N-nitroso-N-alkylureas which ...