Original approach to new derivatives of [1, 3] oxazolo [4, 5-d] pyrimidine

VM Sviripa, AA Gakh, VS Brovarets, AV Gutov…

Index: Sviripa, Vitaliy M.; Gakh, Andrei A.; Brovarets, Vladimir S.; Gutov, Aleksei V.; Drach, Boris S. Synthesis, 2006 , # 20 p. 3462 - 3466

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Citation Number: 15

Abstract

In contrast, the isomeric [1,3]oxazolo[4,5-d]pyrimidines II (Figure [1] ) are poorly studied. Some have been obtained from 4-amino-5-hydroxypyrimidine and its derivatives by condensations with ortho esters [10] [11] and benzoic anhydrides. [12] These methods are obviously unsuitable for the introduction of functional substituents at position 7 of the [1,3]oxazolo[4,5-d]pyrimidine system. The formation of 2-phenyl-[1,3]oxazolo[4,5-d]pyrimidin-7-one by isomerization of ...