The preparation of protoheme mono-N-(5-(2-methyl-1-imidazolyl) pentyl) amide and its oxygenation.

E Tsuchida, H Nishide, Y Sato, M Kaneda

Index: Tsuchida, Eishun; Nishide, Hiroyuki; Sato, Yoshinori; Kaneda, Manabu Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 6 p. 1890 - 1895

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Citation Number: 19

Abstract

Iron (II) protoporphyrin IX N-[5-(2-methyl-1-imidazolyl) pentyl] amide ethyl ester (1) and its derivatives (2–4) were prepared. They predominantly form pentacoordinate heme complexes in organic and aqueous solutions, based on their 2-methylimidazole-ligand and spacer N-pentylamide groups. Oxygen adducts of 1–4 were rapidly formed on exposure to oxygen in N, N-dimethylformamide (DMF) at− 30° C, and their life-times were more than ...