Abstract A series of five 8-substituted α-[bis (2-hydroxyethyi) aminoethyl] naphtho [2, 1-b] thiophenes 7 and a series of seven N-(3-dimethylaminopropyl)-8-substituted naphtho [2, 1- b] thiophene-4-carboxamides 8 have been synthesized. The naphtho [2, 1-b] thiophene-4-