Substituted (aryloxy) alkanoic acids as antagonists of slow-reacting substance of anaphylaxis

…, M O'Donnell, DL Brown, HJ Crowley…

Index: LeMahieu; Carson; Han; Nason; O'Donnell; Brown; Crowley; Welton Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 173 - 178

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Citation Number: 6

Abstract

A series of compounds in which the 4-acetyl-3-hydroxy-2-propylphenoxy moiety of the standard SRS-A antagonist, FPL-55712, is linked by a polymethylene or a polyether chain to substituted (ary1oxy) alkanoic acids was prepared. The compounds were evaluated for their ability to antagonize SRS-A-induced contractions of guinea pig ilea and LTE-induced bronchoconstriction in the guinea pig. The results showed that the compounds were all ...