Synthesis and biological activity of cysteine and thiazaolidine-4-carboxylic acid derivatives

IF Faermark, GY Shvarts, SI Grizik…

Index: Faermark, I. F.; Shvarts, G. Ya.; Grizik, S. I.; Granik, V. G. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 4 p. 264 - 269 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 4 p. 35 - 38

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Abstract

The structure of this compound as an N-acyl (and not an S-acyl) derivative is clearly established by its IH-NMR spectra. The multiplicity and relative intensity of signals corresponding to CH-and NH-group protons confirms structure II. Indeed, the NH proton spectral signal was observed in the form of a doublet at 6.74 ppm (3JNH, C N-7.6 Hz) due to the spinspin interaction with the CH proton, which appears at 4.87 ppm (quartet). The ...