We report herein, on a new fluorescent cavitand derivative bearing four imidazolium groups as well as four pyrene groups as a fluorescent receptor for GTP. The binding properties toward various anions were investigated based on the fluorescence experiments. To our knowledge, host 1 is the first fluorescent cavitand, which displays a selective fluorescent change with GTP. ... Our synthesis began with tetrahydroxy-cavitand, which was prepared following the published ...