The Effect of Alkyl-Substitution in Drugs--V. Synthesis and Chemical Properties of Some Dibenzo [a, d] 1, 4-cycloheptadienyl Ethers

C Van der Stelt, AF Harms…

Index: van der Stelt,C. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 4, p. 335 - 349

Full Text: HTML

Citation Number: 19

Abstract

The relationship between structure and biological activity has been approached by us in recent years by studying, among other things, how the chemical, physicochemical and pharmacological properties of benzophenones, benzhydrols and benzhydryl amino ethers are altered by substitution, especially alkyl substitution. The results of the study of series of substituted dimethylaminoethyl benzhydryl ethers1i2 pointed to a strong influence of the ...