Pharmaceutical Chemistry Journal

Dependence of the M-cholinomimetic properties of arecoline analogs on the structural peculiarities of their molecules

NI Kudryashova, NA Losev

Index: Kudryashova, N. I.; Losev, N. A. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 2 p. 127 - 130 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 2 p. 180 - 184

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Abstract

Arecoline (I) produces a pronounced M-cholinomimetic effect, and, as a tertiary lipidsoluble amine, it penetrates well through the blood-brain barrier, exerting a stimulating influence on the central M-cholinoreceptors, resulting in characteristic tremors [i]. In view of this, I is widely