Tetrahedron letters

A convenient one-pot synthesis of 4-, 6-, and 7-azaindoles from aminopyridines

SD Debenham, A Chan, K Liu, K Price, HB Wood

Index: Debenham, Sheryl D.; Chan, Audrey; Liu, Kun; Price, Karen; Wood, Harold B. Tetrahedron Letters, 2005 , vol. 46, # 13 p. 2283 - 2285

Full Text: HTML

Citation Number: 12

Abstract

Azaindoles are an important component of many natural products and pharmaceuticals. 1 Methods used to construct azaindoles have included palladium(0)-catalyzed coupling of acetylenes and iodinated aminopyridines, 2a, 2b and 2c palladium-catalyzed annulation of chloroaminopyridines with ketones, 2d Madelung-type cyclizations, 3 Pictet–Spengler reaction followed by dehydrogenation, 4 modified Reissert reactions, 1f and 5b Lorenz-type cyclization, 5a ...