The 2-ketopyrrole moiety, although rarely reported, is apparently biologically important as evidenced by its presence in naturally occurring molecules such as X-14547A, 1., and and A-23187 (calcimycin). 2 Generally, 2-acetyl pyrroles are prepared by the Vilsmeier–Haack method using POCl 3 and N,N-dimethylacetamide. 3., , , and Other methods for the acylation of pyrroles involve the isomerization of N-acetyl pyrroles by thermal rearrangement at high temperature, ...
