Elemental Fluorine. Part 21.(1) Direct Fluorination of Benzaldehyde Derivatives

RD Chambers, G Sandford, J Trmcic…

Index: Chambers, Richard D.; Sandford, Graham; Trmcic, Jelena; Okazoe, Takashi Organic Process Research and Development, 2008 , vol. 12, # 2 p. 339 - 344

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Citation Number: 19

Abstract

Direct fluorination of a range of benzaldehyde derivatives gives mixtures of fluorobenzaldehyde and benzoyl fluoride products in ratios that depend upon the nature of the ring substituent. Electron-withdrawing substituents give predominantly benzoyl fluoride derivatives, whereas electron-donating substituents lead to fluoroarene systems. Separation of ring-fluorinated products can be easily accomplished by esterification of the benzoyl ...