Synthesis and biological evaluation of N-substituted-3, 5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors

…, A Bolasco, F Manna, F Rossi, F Orallo, F Ortuso…

Index: Fioravanti, Rossella; Bolasco, Adriana; Manna, Fedele; Rossi, Francesca; Orallo, Francisco; Ortuso, Francesco; Alcaro, Stefano; Cirilli, Roberto European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 6135 - 6138

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Citation Number: 67

Abstract

Eighteen new 1-N-substituted-3, 5-diphenyl-2-pyrazoline derivatives have been synthesized and cyclooxygenase (COX-1 and COX-2) inhibitory activities have been evaluated. The results of these biological assays showed that all of new derivatives are not endowed with improved anti-inflammatory activity against COX-1, but some of them showed a good activity against COX-2. To evaluate the binding mode of the most significative compounds (2d, 2f, ...