Hydrogen-bonding-mediated anthranilamide homoduplexes. Increasing stability through preorganization and iterative arrangement of a simple amide binding site

…, JB Lin, YX Xu, XB Shao, XK Jiang…

Index: Zhu, Jiang; Lin, Jian-Bin; Xu, Yun-Xiang; Shao, Xue-Bin; Jiang, Xi-Kui; Li, Zhan-Ting Journal of the American Chemical Society, 2006 , vol. 128, # 37 p. 12307 - 12313

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Citation Number: 53

Abstract

This paper describes the assembly of two new series of self-complementary duplexes by making use of amide units, the simplest assembling units of hydrogen bonding, as binding sites. All the new monomers possess a rigidified anthranilamide skeleton, which is stabilized by intramolecular hydrogen bonding. Amide units are iteratively introduced to one side of the preorganized skeletons to facilitate the formation of intermolecular hydrogen bonding. ...