Aminomethylthiophene-2-carboxylic acids as dipeptide mimetic in new growth hormone secretagogues

…, K Madsen, BS Hansen, NL Johansen

Index: Peschke, Bernd; Madsen, Kjeld; Hansen, Birgit Sehested; Johansen, Nils Langeland Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 1969 - 1972

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Citation Number: 11

Abstract

3-Aminomethylbenzoic acid is a well established dipeptide mimetic. Herein, aminomethylthiophene-2-carboxylic acids1) have been synthesized as analogues of 3- aminomethylbenzoic acid. Their use as a dipeptide-mimetic at the N-terminal of novel growth hormone secretagogues is described.