Synthetic Studies Directed towards Agelasine Analogs–Synthesis, Tautomerism, and Alkylation of 2??Substituted N??Methoxy??9??methyl??9H??purin??6??amines

H Roggen, LL Gundersen

Index: Roggen, Heidi; Gundersen, Lise-Lotte European Journal of Organic Chemistry, 2008 , # 30 p. 5099 - 5106

Full Text: HTML

Citation Number: 6

Abstract

Abstract N-Methoxy-9-methyl-9H-purin-6-amines, carrying various substituents in the 2 positions, were synthesized by the N-methylation of known 6-chloropurines, followed by a displacement of the chlorine. Great variations in the amino/imino tautomer ratio among the compounds studied were observed. The tautomers were identified by NMR methods. Treatment of N-methoxy-9-methyl-9H-purin-6-amines carrying alkyl, alkoxy, or amino ...