(Ph, P), Pd (5%), DBU, THF, 66" C, H, O (2 equiv), Me, SO, 15-25" C. 12 h. aqueous K, CO,. e 40" C. of this route for asymmetric synthesis, an important feature for the synthesis of natural products. Previous methods of cyclopentenone annulati~ n~~,~ have generally not been used for the synthesis of bicyclo [3.3. 0] compounds, and most are not applicable to the synthesis of 2 because of the known tendencies of 2, 2-disubstituted-1, 3- ...
