Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone

…, P Williams, B Kellam, DI Pritchard…

Index: Jadhav, Gopal P.; Chhabra, Siri Ram; Telford, Gary; Hooi, Doreen S. W.; Righetti, Karima; Williams, Paul; Kellam, Barrie; Pritchard, David I.; Fischer, Peter M. Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3348 - 3359

Full Text: HTML

Citation Number: 12

Abstract

The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l- homoserine lactone (1) is involved not only in bacterial activation but also in subversion of the host immune system, and this compound might thus be used as a template to design immunosuppressive agents, provided derivatives devoid of quorum-sensing activity could be discovered. By use of a leukocyte proliferation assay and a newly developed ...