Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist

F Epifano, S Genovese, EJ Squires, MA Gray

Index: Epifano, Francesco; Genovese, Salvatore; James Squires; Gray, Matthew A. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3130 - 3135

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Citation Number: 10

Abstract

A series of 29 oxyprenylated and azoprenylated phenylpropanoids were chemically synthesized and tested in transfected cultured HepG2 cells by means of the dual-luciferase assay as farnesoid X receptor (FXR) agonists, using the endogenous ligand chenodeoxycholic acid (CDCA) as reference drug. Among the tested molecules, three compounds, namely auraptene, nelumol A, and nelumal A showed a potency comparable ...