… structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted …

P Hewawasam, W Fan, J Knipe, SL Moon…

Index: Hewawasam, Piyasena; Fan, Wenhong; Knipe, Jay; Moon, Sandra L.; Boissard, Christopher G.; Gribkoff, Valentin K.; Starrett Jr., John E Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1779 - 1783

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Citation Number: 78

Abstract

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.