Nucleosides, Nucleotides, and Nucleic Acids

New AZT conjugates as potent ANTI-HIV agents

Z You, HJ Lee

Index: You, Zhengqing; Lee, Henry Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 1 p. 37 - 54

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Citation Number: 3

Abstract

In an attempt to discover anti-HIV agents with much reduced cytotoxicity from the currently available HIV-reverse transcriptase inhibitors, AZT conjugates of cholanic acids, 2- imidazolidone-4-carboxylic acid and its derivatives, and N, N′-disubstituted 5-hydroxy- tetrahydropyrimidin-2-ones have been synthesized and their anti-HIV profiles determined with CEM-SS cell line. The AZT conjugates with 2-imidazolidone-4-carboxylic acid and 2- ...