Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2, 5-disubstituted-8-quinolinamines and some of their amino acid conjugates

M Jain, S Vangapandu, S Sachdeva, R Jain

Index: Jain, Meenakshi; Vangapandu, Suryanarayana; Sachdeva, Sandeep; Jain, Rahul Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1003 - 1010

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Citation Number: 26

Abstract

Thirteen new analogues (32–40, 45–48) of recently discovered potent blood-schizontocidal antimalarial agent, 2-tert-butylprimaquine (2) are synthesized and evaluated for in vivo antimalarial activities against drug-sensitive P. berghei strain and multi-drug resistant P. yoelii nigeriensis strain. Two of the amino acid conjugates (47–48) have exhibited potent antimalarial activities similar to that of 2 against both drug-sensitive and multi-drug ...