A series of 4-(4-alkoxylphenyl)-3-ethyl-4H-1, 2, 4-triazole derivatives was synthesized as open-chain analogues of 7-alkoxyl-4, 5-dihydro [1, 2, 4] triazolo [4, 3-a] quinolines. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES test) and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox). MES test showed that 3-ethyl-4-(4-octyloxyphenyl)-4H-1, 2, 4-triazole 3q was found to be the most potent ...
