Tetrahedron letters

Practical and efficient synthesis of N-halo compounds

…, DR Gauthier, J Lee, D Askin, UH Dolling, RP Volante

Index: Zhong, Yong-Li; Zhou, Hua; Gauthier, Donald R.; Lee, Jaemoon; Askin, David; Dolling, Ulf H.; Volante, Ralph P. Tetrahedron Letters, 2005 , vol. 46, # 7 p. 1099 - 1101

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Citation Number: 32

Abstract

N-Halo compounds are versatile reagents and have been employed as potentially reactive intermediates that are widely used in organic synthesis. 1 Numerous methods utilizing an electrophilic halogen source have been studied to achieve the N-halogenation of amines and amides. 2 Sodium hypohalites (bleach and NaOBr), tert-butyl hypochlorite, and N-halo succinimides (NCS and NBS) are the most common reagents used to perform this N–H to N–X oxidation. However, these ...