e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Thiazoles and thiopyridines: novel series of high affinity h5HT 7 ligands
CG Thomson, MS Beer, NR Curtis, HJ Diggle…
Index: Thomson, Christopher G.; Beer, Margaret S.; Curtis, Neil R.; Diggle, Helen J.; Handford, Emma; Kulagowski, Janusz J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 677 - 680
A series of thiazole based 5HT7 ligands has been identified from screening. Optimisation of the pendent aryl group and modification of the core gave a related series of high affinity, selective thiopyridine based 5HT7 ligands, the most active of which behaves as a partial agonist.
