Bioorganic & medicinal chemistry

Synthesis and pharmacological assessment of derivatives of isoxazolo [4, 5-d] pyrimidine

E Wagner, L Becan, E Nowakowska

Index: Wagner, Edwin; Becan, Lilianna; Nowakowska, Elzbieta Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 265 - 272

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Citation Number: 55

Abstract

A series of new 5-alkyl and 5-arylisoxazolo [4, 5-d] pyrimidinones (5a–g, 6–8) were prepared from 4-amino-3-oxo-isoxazolidine-5-carboxylic acid amide. Some of the aryl derivatives of isoxazolo [4, 5-d] pyrimidine were tested pharmacologically in comparison with Diazepam. Compounds 5b–d and 7 demonstrated interesting anxiolytic activity.