Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative

…, C Woo, S Awale, S Kadota, D Carrico-Moniz

Index: Devji, Tehsina; Reddy, Claire; Woo, Christina; Awale, Suresh; Kadota, Shigetoshi; Carrico-Moniz, Dora Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5770 - 5773

Full Text: HTML

Citation Number: 52

Abstract

A series of hydroxycoumarin derivatives has been synthesized and evaluated against human pancreatic PANC-1 cancer cells under nutrient-deprived conditions. Several compounds exhibited 100% preferential cytotoxicity at low micromolar concentrations under nutrition starvation, and showed no cytotoxicity under nutrient-rich conditions. In this study, a novel geranylgeranylated ether coumarin derivative 9 was found to exhibit the highest ...