Index: Lemke, Thomas L.; Cramer, Michael B.; Adamski, Stanley W.; Pedone, Carolyn A.; Brooker, Gary Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1211 - 1214
A series of y-methyl-(5) and a-methyl (ary1oxy) propanolamines (6) were synthesized and evaluated for@-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for &antagonist action on guinea pig atria and &antagonist action on guinea pig tracheal strip. Several y-methyl (ary1oxy) propanolamines showed af! inity for B receptors ...
