e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of substituted N-[3-(3-methoxyphenyl) propyl] amides as highly potent MT 2-selective melatonin ligands
Y Hu, MKC Ho, KH Chan, DC New, YH Wong
Index: Hu, Yueqing; Ho, Maurice K.C.; Chan, King H.; New, David C.; Wong, Yung H. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2582 - 2585
A series of substituted N-[3-(3-methoxyphenyl) propyl] amides were synthesized and their binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was discovered that a benzyloxyl substituent incorporated at C6 position of the 3-methoxyphenyl ring dramatically enhanced the MT2 binding affinity and at the same time decreased MT1 binding affinity.
