Il Farmaco

Synthesis and structural characterization of derivatives of 2-and 3-benzo [b] furan carboxylic acids with potential cytotoxic activity

J Kossakowski, K Ostrowska, E Hejchman, I Wolska

Index: Kossakowski, Jerzy; Ostrowska, Kinga; Hejchman, Elzbieta; Wolska, Irena Farmaco, 2005 , vol. 60, # 6-7 p. 519 - 527

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Citation Number: 31

Abstract

Derivatives of 2-and 3-benzo [b] furancarboxylic acids were prepared and evaluated for their cytotoxic potential in the National Cancer Institute, Bethesda, USA. Six compounds: 7-acetyl- 6-hydroxy-3-methyl-2-benzofurancarboxylic acid (2), 6-hydroxy-7-(p-methoxycinnamoyl)-3- methyl-2-benzofurancarboxylic acid (4), 5-bromo-7-hydroxy-6-methoxy-2- benzofurancarboxylic acid methyl ester (6a), 6-acetyl-5-(O-ethyl-2′-diethylamino)-2- ...