Tetrahedron letters

On the preparation of enantiomerically pure isonitriles from amino acid esters and peptides

J Zhu, X Wu, SJ Danishefsky

Index: Zhu, Jianglong; Wu, Xiangyang; Danishefsky, Samuel J. Tetrahedron Letters, 2009 , vol. 50, # 5 p. 577 - 579

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Citation Number: 40

Abstract

Initially discovered in 1867 by Gautier 1 and Hofmann 2 , isonitriles have emerged as a synthetically useful class of organic compounds. A number of important isonitrile-based methods had been developed, including the Passerini reaction 3 and the Ugi 4-component coupling reaction, 4 among others. 5 We recently reported a novel thermally induced two-component coupling reaction between isonitriles and carboxylic acids, which provides ready access to various N-formyl ...