Novel Base-Labile Protecting Groups for 5′-Hydroxy Function in Solid-Phase Oligonucleotide Synthesis

K Kamaike, T Namiki, E Kawashima

Index: Kamaike, Kazuo; Namiki, Takashi; Kawashima, Etsuko Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 1011 - 1015

Full Text: HTML

Citation Number: 1

Abstract

Abstract The 6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl (LMM o NBz) and 2- (levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl (LMM p NBz) groups were developed as novel base-labile protection for the 5′-hydroxy function in solid-phase oligonucleotide synthesis. A comparative study of the LMM o NBz, LMM p NBz and 2-(levulinyloxymethyl)-5- nitrobenzoyl (LMNBz) protecting groups for oligonucleotide synthesis proved strong ...