Synthesis and antiviral activity of a new series of 4-isothiazolecarbonitriles

…, G Tempera, E Geremia, MR Pinizzotto…

Index: Cutri, Christian C. C.; Garozzo, Adriana; Siracusa, Maria A.; Sarva, Maria C.; Tempera, Gianna; Geremia, Ernesto; Pinizzotto, Maria R.; Guerrera, Francesco Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2271 - 2280

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Citation Number: 25

Abstract

A series of 4-isothiazolecarbonitriles was synthesized and screened for in vitro antiviral activity. The effect of various substituents on the phenyl ring, as well as the substitution of the phenyl for other aromatic and heteroaromatic rings, was examined to establish the requirements for optimum activity. The most active member of the series, 3-methylthio-5- phenyl-4-isothiazolecarbonitrile, exhibited a high level of activity against enteroviruses ...