Journal of the American Chemical Society

A Michael reaction of lawsone

HE Zaugg

Index: Zaugg Journal of the American Chemical Society, 1949 , vol. 71, p. 1890

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Citation Number: 8

Abstract

In connection with the preparation of various 3-substituted-2-hydroxy-1, 4-naphthoquinones for application to antimalarial studies, the present author found that lawsone (2-hydroxy-l, 4- naphthoquinone) would react with benzalacetone in pyridine to give an addition product resulting from a Michael type reaction. In this respect, Iawsone is similar in reactivity to 4- hydroxycoumarin which likewise has been found2 to add to various a, p-unsaturated ...