2, 3-Dihydro-3-(1-pyrryl) spiro [benzofuran-2, 4'-piperidine] s and 2, 3-dihydro-3-(1-pyrryl) spiro [benzofuran-2, 3'-pyrrolidine] s: novel antihypertensive agents

L Davis, MN Agnew, RC Effland, JT Klein…

Index: Davis; Agnew; Effland; Klein; Kitzen; Schwenkler Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1505 - 1510

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Citation Number: 7

Abstract

metalated with n-butyllithium in tetrahydrofuran at-80 “C and then reacted with 1-methyl-4- piperidone or 1-benzyl-3-pyrrolidone (method A) to give the alcohols 2 and 3 in good yield. The alcohols 2 and 3 were cyclized to the spiro compounds 4 and 5 through a base-induced nucleophilic displacement of fluoride with sodium hydride in a