Pd/P (t-Bu) 3: a mild and general catalyst for Stille reactions of aryl chlorides and aryl bromides

AF Littke, L Schwarz, GC Fu

Index: Littke, Adam F.; Schwarz, Lothar; Fu, Gregory C. Journal of the American Chemical Society, 2002 , vol. 124, # 22 p. 6343 - 6348

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Citation Number: 429

Abstract

Pd/P (t-Bu) 3 serves as an unusually reactive catalyst for Stille reactions of aryl chlorides and bromides, providing solutions to a number of long-standing challenges. An unprecedented array of aryl chlorides can be cross-coupled with a range of organotin reagents, including SnBu4. Very hindered biaryls (eg, tetra-ortho-substituted) can be synthesized, and aryl chlorides can be coupled in the presence of aryl triflates. The method is user-friendly, ...