Organic letters

Highly efficient route to o-allylbiaryls via palladium-catalyzed three-component coupling of benzynes, allylic halides, and aryl organometallic reagents

TT Jayanth, M Jeganmohan, CH Cheng

Index: Jayanth, Thiruvellore Thatai; Jeganmohan, Masilamani; Cheng, Chien-Hong Organic Letters, 2005 , vol. 7, # 14 p. 2921 - 2924

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Citation Number: 61

Abstract

Palladium-catalyzed three-component coupling reactions based on an oxidative addition, insertion of the resulting organopalladium species into multiple bonds (carbopalladation), and followed by transmetalation have fundamentally revolutionized synthetic concepts for the formation of carbon−carbon and carbon−heteroatom bonds. 1 Among these reactions, those that involve carbopalladation of alkynes, 2 alkenes, 3 and allenes 4 have proven to be extraordinarily ...