General and Selective Head-to-Head Dimerization of Terminal Alkynes Proceeding via Hydropalladation Pathway

…, OV Zatolochnaya, NV Zvyagintsev, VP Ananikov…

Index: Jahier, Claire; Zatolochnaya, Olga V.; Zvyagintsev, Nickolay V.; Ananikov, Valentine P.; Gevorgyan, Vladimir Organic Letters, 2012 , vol. 14, # 11 p. 2846 - 2849

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Citation Number: 39

Abstract

A general highly regio-and stereoselective palladium-catalyzed head-to-head dimerization reaction of terminal acetylenes is presented. This methodology allows for the efficient synthesis of a variety of 1, 4-enynes as single E stereoisomers. Computational studies reveal that this dimerization reaction proceeds via the hydropalladation pathway.