Journal of Medicinal Chemistry

Steroids. CLXXX. 1 2-Methyl-Δ2-androstenes and 2-Methylene-androstanes. A New Class of Potent Anabolic Agents

AD Cross, JA Edwards, A Bowers

Index: Cross,A.D. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 406 - 408

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Citation Number: 2

Abstract

The recent finding'that a series of A2-androstene analogs had relatively high androgenic and anabolic activities led us to investigate the effects of substitution on this double bond, This communication reports the preparation of some 2-methyl-A*-androstenes as well as their double bond isomers, the corresponding C-2 exocyclic methylene analogs. High anabolic activity with low androgenicity was ohserved for this series of compounds. 2a- ...