Structure–Activity Studies of Diazabicyclo [3.3. 0] octane-Substituted Pyrazines and Pyridines as Potent α4β2 Nicotinic Acetylcholine Receptor Ligands

MJC Scanio, L Shi, WH Bunnelle…

Index: Journal of Medicinal Chemistry, , vol. 54, # 21 p. 7678 - 7692

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Citation Number: 5

Abstract

... Journal of Medicinal Chemistry. ... pain, various other central nervous system (CNS) disorders, and even non-CNS disorders such as cancer.(7-19) Modulating the activity of nAChRs offers potential for the development of new drugs in areas of significant unmet medical need.(20 ...

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[Scanio, Marc J. C.; Shi, Lei; Bunnelle, William H.; Anderson, David J.; Helfrich, Rosalind J.; Malysz, John; Thorin-Hagene, Kirsten K.; Van Handel, Ceclia E.; Marsh, Kennan C.; Lee, Chih-Hung; Gopalakrishnan, Murali Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7678 - 7692]