Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers*

MG Kallitsakis, DJ Hadjipavlou-Litina…

Index: Kallitsakis, Michael G.; Hadjipavlou-Litina, Dimitra J.; Litinas, Konstantinos E. Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 4 p. 765 - 775

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Citation Number: 6

Abstract

Cross metathesis (CM) of 9-butenylpurines with 4-butenyloxycoumarin in the presence of Grubbs 2nd generation catalyst under MW irradiation resulted to conjugated compounds containing homo-N-nucleosides and coumarins. Analogous derivatives received by the CM reaction of 9-butenyl-6-piperidinylpurine with 6-or 7-butenyloxycoumarins, allyloxycoumarins or coumarinyl acrylate. These compounds were tested in vitro for their ...