Organic & biomolecular chemistry

Simplified dynemicin analogues: diastereoselective synthesis and evaluation of their activity against plasmid DNA

G Guanti, R Riva

Index: Guanti, Giuseppe; Perrozzi, Sara; Riva, Renata Tetrahedron Asymmetry, 2002 , vol. 13, # 24 p. 2703 - 2706

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Citation Number: 16

Abstract

The total synthesis of two diastereoisomeric simplified dynemicin analogues is reported. The key steps involved are: the regio-and diastereoselective functionalisation of an appropriate racemic quinoline precursor and the ring closure to give the 10-membered enediyne moiety

32830-97-0

1-CHLORO-3-PENTANONE

74497-02-2

~50%

19020-26-9

4-ethylquinoline

Novel Series of Potent, Nonsteroidal, Selective Androgen Rec...

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Synthesis of nitrogen heterocycles via palladium-catalyzed i...

[Larock, Richard C.; Babu, Srinivasan Tetrahedron Letters, 1987 , vol. 28, # 44 p. 5291 - 5294]

Synthesis of 4??vinylquinoline: Pyrolytic rearrangement of t...

[Rodriguez, J. G.; Benito, Y. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 819 - 821]

Regioselective synthesis of 4-alkylquinolines from quinoline...

[Akiba, Kin-ya; Kasai, Tetsuji; Wada, Makoto Tetrahedron Letters, 1982 , vol. 23, # 16 p. 1709 - 1712]

SALTS OF THE AMMONO ENOLIC MODIFICATION OF PYRIDINES AND QUI...

[Bergstrom Journal of the American Chemical Society, 1931 , vol. 53, p. 4065,4076]