Il Farmaco

Synthesis and antihypertensive activity of 2, 4-dioxoimidazolidin-1-yl and perhydro-2, 4-dioxopyrimidin-1-yl ergoline derivatives

S Mantegani, E Brambilla, C Caccia, L Chiodini…

Index: Mantegani, Sergio; Brambilla, Enzo; Caccia, Carla; Chiodini, Laura; Ruggieri, Daniela; Lamberti, Ernesto; Di Salle, Enrico; Salvati, Patricia Farmaco, 1998 , vol. 53, # 4 p. 293 - 304

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Citation Number: 10

Abstract

The synthesis and antihypertensive activity of a series of 2, 4-dioxoimidazolidin-1-yl and perhydro-2, 4-dioxopyrimidin-1-yl ergoline derivatives are reported. The oral antihypertensive activity was studied in spontaneously hypertensive rats (SHRs) by measuring systolic blood pressure by an indirect tail-cuff method at different times after treatment. The prolactin lowering activity (indirectly measured by the nidation test) in rats ...