5-fluoro-2-methyl-N-[5-(5H-pyrrolo [2, 1-c][1, 4] benzodiazepine-10 (11H)-yl carbonyl)-2-pyridinyl] benzamide (CL-385004) and analogs as orally active arginine …

…, J Coupet, X Ru, T Saunders, H Mazandarani

Index: Aranapakam, Venkatesan; Albright, J. Donald; Grosu, George T.; Delos Santos, Efren G.; Chan, Peter S.; Coupet, Joseph; Ru, Xun; Saunders, Trina; Mazandarani Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 13 p. 1737 - 1740

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Citation Number: 21

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Synthesis and structure-activity relationships (SAR) of orally active arginine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A or VPA-985 (1) is replaced with a 3-pyridinyl unit (2).